acetylcholine antagonist造句
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- These compounds were also found to act as selective ? 3 ? 4 nicotinic acetylcholine antagonists, with little or no effect on NMDA receptors.
- In its role as a synthetic acetylcholine antagonist, biperiden has been analyzed as an alternative anticonvulsant for usage in the treatment of intoxication by organophosphorus nerve agents, such as sarin.
- Similarly to 18-MC itself, 18-MAC acts primarily as a selective ? 3 ? 4 nicotinic acetylcholine antagonist, and is even more selective than 18-MC with very little activity as an NMDA antagonist and only slight affinity for the delta opioid receptor.
- In animal studies it has shown similar efficacy to the related compound 18-methoxycoronaridine ( 18-MC ) at reducing self-administration of morphine and methamphetamine but with higher potency by weight, showing anti-addictive effects at the equivalent of half the minimum effective dose of 18-MC . Similarly to 18-MC itself, ME-18-MC acts primarily as a selective ? 3 ? 4 nicotinic acetylcholine antagonist, although it has a slightly stronger effect than 18-MC as an NMDA antagonist, and its effects on opioid receptors are weaker than those of 18-MC at all except the kappa opioid receptor, at which it has slightly higher affinity than 18-MC.
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